Thursday, 12 December 2013

"Rolling"


"Rolling"
This is a confocal microscope image of a capillary. In this particular case, there are white blood cells interacting with the venular wall in an inflamed tissue.
To do their defensive action, white cells must be carried by the blood stream situated in the connective tissue to the site of inflamation in the organ tissue, where they search out and destroy pathogens.

This phase of acute inflammation is technically called “Rolling”: leukocytes (usually neutrophils) roll along the endothelial surface, they are activated and firmly adhere, they eventually migrate across the endothelial cell wall.

Source:
http://www.bme.rochester.edu/research/projects/project.php?res=2&proj=26

11 comments:

  1. Impressive! Do you have an idea of the scale? It's the first time I see a SEM video. Normally we are more used to static images.

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  2. ACZEL SANCHEZ that's what we need to do. :-)

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  3. Not really, but maybe Chad Haney can help us out since he is the imaging guru =)
    Thanks in advance!

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  4. I'm guessing this is not TEM but a confocal microscope image with 1.8 micron resolution.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191564/

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  5. Mathieu Hautefeuille looks like I was wrong, see the answer of Chad.

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  6. I'm just guessing Corina Marinescu

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  7. I'm sure your guru "guess" is better than mine, after all I never paid too much attention to imaging in med school. 
    Anyways, danke!

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  8. Corina Marinescu Chad Haney Many thanks. It could look like a SEM but I don't think you can get a flow inside the vacuum chamber and visualize it. Can you?
    Thanks again

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  9. Jon Hiller would know the answer but my guess is that TEM and SEM cannot do this experiment.

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