The Apollo 9 mission was the first manned flight of all Apollo lunar hardware in Earth orbit and first manned flight...

The Apollo 9 mission was the first manned flight of all Apollo lunar hardware in Earth orbit and first manned flight of the lunar module. Lunar module pilot Russel L. Schweickart performed a 37 minute EVA. Human reactions to space and weightlessness were tested in 152 orbits.

Source & further reading:
http://airandspace.si.edu/explore-and-learn/topics/apollo/apollo-program/orbital-missions/apollo9.cfm

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