Scientists identify brain cells involved in Pavlovian response

Scientists identify brain cells involved in Pavlovian response
In his famous experiment, Russian scientist Ivan Pavlov rang a bell each time he fed his dogs. Soon, the dogs began drooling in anticipation when they heard the bell, even before food appeared.

A UCLA study has traced the Pavlovian response to a small cluster of brain cells — the same neurons that go awry during Huntington’s disease, Parkinson’s disease and Tourette’s syndrome. Published March 22 in the journal Neuron, the research could eventually help scientists identify new approaches to diagnosing and treating these neurological disorders.

“Species survive because they’ve learned how to link sensory cues like specific sounds, smells and sights to rewards like food and water,” said Sotiris Masmanidis, the study’s senior author and an assistant professor of neurobiology at the David Geffen School of Medicine at UCLA. “We wanted to uncover the brain circuitry that encodes reward-based learning and behavior.”

The UCLA team focused on cellular activity in the striatum, a part of the brain associated with reward, movement and decision-making.

In a modern version of Pavlov’s experiment, Masmanidis and colleagues repeatedly exposed mice to the unfamiliar scent of banana or lemon, followed by a drop of condensed milk. Eventually, the mice learned that the fragrances predicted the arrival of a sweet reward and began fervently licking the air in anticipation.

“The mice learned to associate the new scent with food, just like Pavlov’s dogs,” said Masmanidis, who is also a member of UCLA’s California NanoSystems Institute and Brain Research Institute. “Our next step was to uncover what happens to the Pavlovian response when we silence different groups of cells in the striatum.”

“When we switched off the support cells, the mice licked the air in anticipation of the milk only half as often as normal,” Masmanidis said. “We suspect that the support cells enhance the brain circuits that encode Pavlovian response.”

The findings suggest that neurological disorders could be caused in part by malfunctioning support cells, and that restoring the cells’ function may eventually help people with these diseases.

Source & further reading:
http://newsroom.ucla.edu/releases/study-identifies-brain-cells-involved-in-pavlovian-response

Journal article:
http://www.cell.com/neuron/fulltext/S0896-6273(17)30141-1?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627317301411%3Fshowall%3Dtrue

#neuroscience #striatum #associativelearning #neurologicaldisorders #interneurons #research #brain